Abstract
Castleman disease (CD) is an uncommon lymphoproliferative disorder occurring mostly in patients presenting with mediastinal lymphadenopathy. Predominant phenotypes are categorized as localized hyaline vascular or multicentric plasma cell variants. Localized form of CD is usually asymptomatic and rarely associated with deep venous thrombosis. We report an exceptional case of mediastinal CD, which presented as retrosternal chest pain, in a 42-year old man. Imaging and pathological examination showed an atypical, mixed and localized form of CD. Thoracic CT scan revealed brachiocephalic vein thrombosis. Investigations didn’t reveal other risk factors for deep venous thrombosis. Deep venous thrombosis is an exceptional complication of localized variants of CD. Therefore, it seems worth looking carefully for this last type of benign lymphopathy when an unusual thrombosis is found.
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