Abstract
The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.
Highlights
The benefits of green tea polyphenols consumption have been extensively studied and scientifically established [1,2,3,4]
Analysis of the green tea extracts solutions proved that gallic acid reactivity corresponds to
Since Polyphenon 60® has a defined composition and as a previous step to the oral administration of the Green tea polyphenols (GTPs) characterized green tea extracts, a standard solution of 30 mg/kg body weight of Pol60 were orally administered to Swiss mice with neither visible damage nor reduction of the body weight (Figure 2)
Summary
The benefits of green tea polyphenols consumption have been extensively studied and scientifically established [1,2,3,4]. Green tea polyphenols (GTPs) display specific beneficial effects on health and pathologies, especially in cardiovascular disorders and cancer [5,6], as well as in inflammatory bowel diseases (IBD), especially at low doses [7]. GTPs are highly active molecules which trigger antagonistic effects depending on the concentration used, acting as prooxidant [8] or antioxidant [6]. Among the most important effects described in the literature are the anti-inflammatory [9], antioxidant [10], anticancer [6,11,12,13], and antibacterial biofilm process actions [14]. Among the green tea catechins, epigallocatechin gallate (EGCG) has been by far the most studied. EGCG acts on targets, for instance, on very complex mechanisms like cancer through apoptosis of cancer cells [16,17]
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