Abstract
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells is an exceptionally rare malignancy, with fewer than 100 cases reported to date. While the histological features of this entity have been well described, cytological diagnosis can present a challenge. This case report describes the cytological features of a fine needle aspirate from a heterogenous pancreatic mass in a 75-year-old man. The smears revealed singularly dispersed and clustered cells with marked atypia in a background of histiocytes and osteoclast-like multinucleated giant cells.
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