Abstract
Stroke is the fifth leading cause of death and disability in the United States. According to World Heart Federation, every year, 15 million people suffer from stroke worldwide out of which nearly 6 million people die and another 5 million people are disabled. Out of many organs affected after stroke, one of them is eye. Majority of the stroke victims suffer vision loss due to stroke-induced retinal damage. However, stroke-induced retinal damage and microvascular changes have not been given paramount importance in understanding stroke pathophysiology and predicting its occurrence. Retinal imaging can be a very powerful tool to understand and predict stroke. This review will highlight the importance of retinal changes in predicting occurrence of stroke, major retinal changes, the relationship between retinal diseases and stroke and moreover, molecular mechanisms delineating the stroke induced-retinal changes and therapeutics associated with it.
Highlights
Stroke is one of the leading causes of adult death and disabilities in the world
Stroke is a cerebrovascular accident caused by interruption of the blood supply to the brain
The functions of various organs including eye are compromised differently depending upon the affected parts of the brain after stroke and its severity
Summary
Stroke is one of the leading causes of adult death and disabilities in the world. According to American Heart association, it is the fifth leading cause of death and long term disability in the United States [1]. FDA approved treatment for stroke is tissue plasminogen activator (tPA), which is a thrombolytic agent. Detection of early pathological changes after stroke can lead to new therapeutic targets. There is an unmet need to investigate an area of brain, which is similar in vasculature and physiological changes, accessible and can be examined with noninvasive or minimally invasive methods so that such organ may become a direct window to the cerebral pathology. Eye, being one such part of brain, projects out of diencephalon, has similar embryonic origin, vasculature, blood barriers and pathophysiology. This review has been developed in a certain fashion as depicted in the flow chart diagram (Table 1) and summarizes important findings in the field of eye and stroke research (Table 2)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
