Abstract

Alzheimer's Disease Alzheimer's disease (AD) is characterized by abnormal protein accumulation in the extracellular milieu in the brain. The endosomal pathway is responsible for proteolytic cleavage and secretion of proteins, and recent data have shown that a defective endosomal pathway contributes to AD pathogenesis. However, which proteins are affected by defective endosomal pathways is still unclear. Simoes et al. performed proteomic analysis in cerebrospinal fluid from mice with defective endosomal trafficking and in patients with AD and showed that the expression of two transmembrane proteins, APLP1 and CHL, was increased and correlated with tau expression. The results provide valuable insights regarding the effect of endosomal trafficking alterations in AD. Sci. Transl. Med. 12 , eaba6334 (2020).

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