Abstract
Nanotechnology has a potential to transform healthcare by improving the quality of drugs and medical devices. The benefits of using nanomaterials in medical devices include improving device durability, decreasing bacterial adhesion and biofilm formation, and providing slow and controlled release of device-associated drugs. Using nanoparticles as implantable materials and components of medical devices also poses some safety concerns and regulatory challenges. This chapter reviews hematological and immunological toxicities relevant to the nanomaterials used in medical devices. Regulatory challenges, translational considerations, and literature case studies pertinent to the immunological safety of nanotechnology-based devices are also discussed.
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