Abstract
Underdiagnosed Paraquat Induced Pneumothorax and Pneumomediastinum, The “Daisley Barton Syndrome”: A Clinical Feature Of Paraquat-Induced Acute Lung Injury
Highlights
The purpose of this manuscript is to highlight the proposed mechanism of paraquat induced acute lung injury, namely pneumothorax and pneumomediastinum
Our case presents the Daisley Barton syndrome as part of paraquat induced acute lung injury which developed in a matter of 2 - 3 days post ingestion
The hydroxyl radical produces lipid radicals, which react with oxygen to form lipid hydroperoxides; such lipid hydroperoxides destroy the integrity of cell membranes allowing cytoplasm to leak into intercellular spaces, which leads to rapid leaf wilting and desiccation [2]
Summary
The purpose of this manuscript is to highlight the proposed mechanism of paraquat induced acute lung injury, namely pneumothorax and pneumomediastinum This entity, as a consequence of paraquat ingestion, was first published by Daisley and Barton in 1990 [1], hitherto called the Daisley Barton syndrome. The patient was a 23-year-old male who presented to the district health facility with vomiting, diarrhea and severe chest and abdominal pain after alcohol binge drinking the night prior. He was assessed as having acute alcoholic gastritis with possible acute pancreatitis and was referred to the General Hospital for further management. Initial blood investigations were normal except for a mildly elevated serum amylase, his renal function declined progressively during his hospital stay (Table 1)
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