Abstract
In this issue of Molecular Therapy, Miller et al. provide a timely and well-constructed demonstration of the influence that murine blood pressure can have on the efficacious delivery to tumors of systemically injected oncolytic viruses.1 The authors compared tumor delivery of vesicular stomatitis virus in mice with blood pressure elevated through exercise or depressed through the use of inhaled anesthesia (isoflurane). Under these contrasting conditions, levels of tumor infection (monitored longitudinally in living animals by daily high-resolution tomographic SPECT/CT imaging of the virally encoded sodium iodide symporter reporter transgene) were elevated as much as twofold in the exercise-treated mice compared to those treated under anesthesia.
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