Abstract
Full and unambiguous asssignment of all 1H- and 13C-NMR resonances of the free bases as well as the hydrochloride salts of the antiarrhythmic agent propafenone and a thiophene analogue in different solutions (DMSO-d6, CDCl3) is reported.
Highlights
Propafenone (1) is a class Ic antiarrhythmic drug with β-adrenoreceptor blocking and calcium antagonistic activity [1,2]
Complete and unambiguous assignments of all proton and carbons resonances were achieved on the basis of chemical shift considerations, coupling information (APT [10] and 'gated decoupled' 13C-NMR spectra), and NOE-difference [11], COSY45 [12], HMQC [13], and 1D-TOCSY [14] spectra as well as on long-range INEPT experiments with selective excitation [15]
We have presented the complete 1H- and 13C-NMR chemical shifts of propafenone (1) and its thiophene analogue 2 as well as some selected spin-spin coupling constants
Summary
Propafenone (1) is a class Ic antiarrhythmic drug with β-adrenoreceptor blocking and calcium antagonistic activity [1,2]. The present communication deals with the completely assigned 1H- and 13C-NMR spectra of propafenone and its thiophene analogue 2 [9], obtained by combined application of one and two-dimensional standard NMR techniques. Complete and unambiguous assignments of all proton and carbons resonances were achieved on the basis of chemical shift considerations, coupling information (APT [10] and 'gated decoupled' 13C-NMR spectra), and NOE-difference [11], COSY45 [12], HMQC [13], and 1D-TOCSY [14] spectra as well as on long-range INEPT experiments with selective excitation [15].
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