Abstract
1. 1. Ultrastructural features of juxtaglomerular cells have been correlated with plasma and kidney analyses from non-hibernating, hibernating and awakening ground squirrels. 2. 2. Juxtaglomerular cells in kidneys from hibernating animals show signs of increased activity. 3. 3. Plasma samples from hibernating animals show a significant increase in magnesium. 4. 4. Kidney analyses from hibernating animals, show glycogen increases and lactate and inorganic phosphate decrease significantly. Adenosine triphosphate remains the same. 5. 5. Maintenance of high-energy phosphates in the hibernating kidney is essential to maintaining sodium transport and osmotic pressure. This coupled with a functional renin-angiotensin system regulates water and electrolyte balance.
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