Abstract
AbstractAscites tumor cells differed from cells of the solid tumor in possessing filamentous structures in the marginal parts of the cytoplasm, in demarcated juxtanuclear areas and in uniform microvillous surface protrusions — “microspikes”. In free cells, dissociated from the solid tumor by trypsin and deoxyribonuclease, filamentous structures and microspikes of the same kind as in ascites tumor cells appeared regularly, evidently as an adaptation to the free‐cell state. In ascites tumor cells, exposure to crude trypsin led to detachment of microspikes and occasionally of larger cytoplasmic buds. Similar effects, although less frequent, occurred after treatment with crystalline trypsin.
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