Abstract
Close organic-inorganic relationships exist in all calcified tissues, the inorganic substance being linked to crystal ghosts (CGs). These are organic, crystal-like structures present in areas of initial calcification. In cartilage and bone, they form aggregates with the same morphology and distribution as the calcification nodules; in enamel, they consist of long filament- and ribbon-like structures, having the same arrangement as untreated crystals. CGs of cartilage and bone are acidic structures with histochemical properties of proteoglycans; CGs of enamel probably correspond to enamelins. The close morphologic similarity between CGs and crystals suggests that the former have a role in the formation of the latter.
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