Abstract
An icosahedral virus was observed in mononuclear leukocytes and heterophils of a mink frog (Rana septentrionalis) and a green frog (Rana clamitans). Infected cells were grossly distorted, often containing a prominent juxtanuclear viroplasm in which nucleocapsids in various stages of assembly occurred. Viral particles were also observed occasionally within the nucleus of some cells. Mature nucleocapsids were usually hexagonal in profile, measuring about 131 ± 9.2 nm in diameter (n = 10) and were arranged in paracrystalline arrays. Individual viral particles were observed at the periphery of infected cells apparently budding from the plasma membrane. These observations extend both the geographic and host ranges of frog leukocytic virus which could serve as a useful model, not only for the study of viral function, but also for its effect on the immune system of the anuran host.
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