Abstract
SUMMARY Sheep were experimentally infected with Leptospira interrogans serotype pomona and after 34 days the kidneys were examined by electron microscopy. Colonisation of the kidneys was well established at this time and changes in the kidney tubules included a concentration of leptospires around the periphery of the proximal tubular lumen. The microvilli making up the brush border were in some instances greatly reduced in numbers and in others the microvilli had developed bulbous ends. Necrotic epithelial cells within the tubules were observed and these were sometimes found free in the tubular lumen. The possible sequence of events leading to these changes is discussed.
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