Abstract
The correlation between ultrastructural changes in gastric epithelia inHelicobacter pylori (HP)-positive chronic gastritis and the amounts of the bacteria was studied. The amounts of bacteria were determined semiquantitatively by a cultural method using gastric biopsy specimens. In an ultrastructural study, vacuolar degeneration, disruption of basement membranes, infiltration of eosinophils and lymphocytes, and HP involvement in gastric epithelial cells were observed. These findings were more conspicuous in the patients who had greater amounts of HP in the stomach. In addition to these findings, the junctional spaces between the gastric epithelia were looser in the patients who had greater amounts of bacteria. These tendencies were milder in the patients who had smaller amounts of HP. in severe HP infections, morphological changes in the gastric tissues seem to add to a vicious circle, perpetuating the condition of chronic gastritis.
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