Abstract
A rapid method was developed to determine the content of tyramine in food on the basis of the combination of molecular imprinting technique and the metal-organic frameworks. We developed the new molecular imprinted polymers based on metal-organic frameworks UiO-66 (named UiO-66@MIPs) as the sensing recognition element, the non-molecular imprinted polymers based on UiO-66 (named UiO-66@NIPs) was synthesized according the same steps without tyramine for comparison. The characterization of obtained UiO-66@MIPs was investigated through a series of characterization experiments. The results indicated that the octahedral shaped UiO-66 was encapsulated in the sol-gel polymer film, with a desirable thermal stability and possessed a specific surface area (SSA) of 994.3 m2·g−1. The imprinting factor of the UiO-66@MIPs for tyramine was 1.956 in static experiment. This indicates the synthesized UiO-66@MIPs have outstanding performance compered to UiO-66@NIPs on the static adsorption quantity and selective adsorption affinity. It’s to make use of advantages of the synthetic materials to develop a quartz crystal microbalance (QCM) sensor for the sensitive detection of tyramine. The detection limit of the system was 61.65 μg·L−1 within measurable concentration range from 80 to 500 μg·L−1. The prepared QCM sensor was verified in selectivity and application. The UiO-66@MIPs possess good behavior on selectivity, absorptivity, and chemical stability, so the UiO-66@MIPs achieve accurate and rapid trace detection of biogenic amines in food combining with the quartz crystal microbalance.
Highlights
IntroductionThe existence of a low content of biogenic amine plays an important physiological role in animals and plants [1]
Biogenic amines are a class of small molecular nitrogen compounds with biological activity.The existence of a low content of biogenic amine plays an important physiological role in animals and plants [1]
Tyramine is metabolized by monoamine oxidase (MAO) [2] and is common in biogenic amines, which widely exists in fermented food or other animal-origin food matrices [3] and it has a great impact on human health [4]
Summary
The existence of a low content of biogenic amine plays an important physiological role in animals and plants [1]. Tyramine is metabolized by monoamine oxidase (MAO) [2] and is common in biogenic amines, which widely exists in fermented food or other animal-origin food matrices [3] and it has a great impact on human health [4]. Food allergens can cause a series of adverse reactions and impair human health. Excess tyramine contributes to an enhanced pressor effect of tyramine in human body [2]. Even, elevated blood pressure and other potential dangerous could take place following exposure to normal amounts of tyramine when using MAO inhibitors (MAOI), due to its inhibition of reducing tyramine [5]. We can see that the incidence of hypertension is closely
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