Abstract
A synthetic biodegradable nerve guide was constructed of two polymeric layers: an inner microporous layer prepared from a copolymer of l-lactide and ϵ-caprolactone (pore size range 0.5–1μm) and an outer microporous layer prepared from a polyurethane/poly( l-lactide) mixture (pore size range 30–70 μm). This nerve guide was used to bridge a 7 mm gap in the right sciatic nerve of rats. It enabled the sciatic nerve to regenerate across the gap, forming a new, well-defined nerve that effectively re-established the contact between the proximial and distal nerve end, as effective as an autograft.
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