Abstract
AbstractTwo novel indole alkaloids with plumeran skeleton, N‐benzoyl‐12‐demethoxycylindrocarine and N‐cinnamoyl‐12‐demethoxycylindrocarine (1 and 2, resp.), were isolated from the MeOH extract of the stem bark of Aspidosperma cylindrocarpon Müll.Arg. These compounds were obtained by high‐speed counter‐current chromatography, and their structures were elucidated on the basis of their NMR (1D and 2D) data. They were tested in vitro against chloroquine‐resistant strains of Plasmodium falciparum, and only 2 showed a weak activity (IC50 127.97 ng/ml with respect to the standard drug). Several other known compounds, comprising steroids, flavonoids, the rarely found atraric acid, as well as the previously reported alkaloid 3, were also isolated by conventional chromatographic techniques.
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