Abstract
Malignant melanoma of ano-rectal region is a very rare lesion and its 5-year survival rate is about IO per cent. Two cases of anorectal malignant melanoma are presented in this paper.According to Japanese General Rules for Clinical and Pathological Studies on Cancer of Colon, Rectum and Anus, first case is Rb, Borr. I, 4×3.5×2 cm, a quater of circ., a2, P0, H0, n(+), R3, absolute curative resection and second case is RbP, Borr. I, 10.5×3×5cm, subcirc. pm, P0, H0, ly1, v2, n(-), R3, absolute curative resection.First case was treated by adjuvant chemotherapy with METT inj. (MMC, Endoxan, Toyomycin, Tespanon).Second case has been treated by immunotherapy with Levamisole and BCG and some recurrence leions were treated with cryosurgery. Both cases survived only 8 months after radical operation.Complete resection with lymphadenectomy and adjuvant-therapy should be carried out in principle because of its high malignaucy.Cryo-immun otherapy is one whon wed of many methodon adjugant immuno-therapy and some benefit may be expected in the treatment for ano-rectal malignant melanoma.
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