Abstract
To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. The colonization rates reached with the TUP1REP-RFPREP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed. Blockage of C.albicans in a filamentous form impedes gut cell colonization in the mouse.
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