Abstract
Tuning WNT-β-catenin signaling via BCL9 proteins for targeting colorectal cancer cells
Highlights
With tumor invasion and metastasis via Bcl9/9l appear to be dispensable for normal intestinal epithelial homeostasis (Deka et al 2010)
A search for human homologs allowed the characterization of a BCL9/9L-KO signature of 378 genes that was used to probe public human Colorectal cancer (CRC) databases revealing that hazards of relapse and death are both significantly reduced in patients displaying BCL9/ 9L-KO-like tumor profiles
These results suggest that CRC cells are very dependent on functional BCL9 proteins for promoting tumor progression via stimulation of stemness and EMT traits and preventing differentiation, a pathway not apparently essential for the maintenance of normal intestinal epithelial homeostasis
Summary
With tumor invasion and metastasis via Bcl9/9l appear to be dispensable for normal intestinal epithelial homeostasis (Deka et al 2010). They first investigated a second CRC mouse model driven by loss of Apc and oncogenic Kras to complement their initial observations performed on the chemically induced mouse CRC model mentioned above (Deka et al 2010) confirming that ablation of Bcl9/9l modulates similar alterations of gene expression in both types of tumors with 359 down- and 107 up-regulated common differentially expressed genes.
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