Abstract
Nitric oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that the NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.
Highlights
Nitric oxide (NO) is an important biological messenger molecule that mediates a variety of biological functions, including inhibition of platelet adhesion and aggregation, vasodilation and cell proliferation, and has been shown to have antibacterial and wound healing properties.[1,2] It is produced naturally in the human body via the conversion of the amino acid, Larginine, to L-citrulline by the enzyme NO synthase (NOS)
The approach can be extended to CPO-27 (Zn), and we expect to other systems too
These results represent a signi cant advance in the development of metal organic frameworks (MOFs) for storage and delivery of controlled concentrations of bio-active NO because they suggest that careful manipulation of the MOF composition enables the NO concentration and resulting arterial relaxation response to be tuned; the concentration of delivered NO and the resulting biological response are no longer limited to those associated with only the pure end members
Summary
Nitric oxide (NO) is an important biological messenger molecule that mediates a variety of biological functions, including inhibition of platelet adhesion and aggregation, vasodilation and cell proliferation, and has been shown to have antibacterial and wound healing properties.[1,2] It is produced naturally in the human body via the conversion of the amino acid, Larginine, to L-citrulline by the enzyme NO synthase (NOS). Similar previous studies have shown that isomorphous substitution of a second metal into MOF frameworks with CPO-27 and rtl topologies can achieve CO2, H2 and methane adsorption values that are intermediate between those of the pure end members, suggesting that gas adsorption can be tuned by altering composition.[22,23] Since CPO-27 (Ni) is known to store and release large quantities of NO, we postulated that doping small amounts of Ni2+ into the framework of CPO-27 (Mg) and (Zn) may achieve NO delivery levels intermediate between those of the pure end members, affording a more tuneable and controllable system that can be tailored to suit many different biomedical applications without the restrictions imposed by the properties of the pure end members.
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