Abstract
Non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represents 78.5% of all skin malignant tumours in Egypt. Dendritic cells can be found in almost all human tumours, they play an important role in antitumour immunity. The aim of the present study was to evaluate the percentage of Langerhans cells using CD1a in non-melanoma skin cancer, including BCC and SCC and to correlate this percentage with their clinicopathological features. The current study was performed on surgically excised specimens of 41 patients presented with non-melanoma skin cancer (26 BCC and 15 SCC) and 16 healthy volunteer control subjects. The mean and median percentage of Langerhans cells were higher in normal epidermis of control compared to malignant tumour tissue (p < 0.0001) and adjacent epidermis overlying malignant tumour tissue (p = 0.007). Langerhans cells were significantly seen in BCC cases more than SCC (p = 0.035) and they were seen in facial lesions more than those arising from other sites (p = 0.007). The reduction of Langerhans cells is a way for non-melanoma skin cancer to develop and progress. Marked reduction of Langerhans cells in SCC compared to BCC could refer to their role as a barrier against metastasis.
Highlights
Skin cancer is the most common cancer in Europe, the United States and Australia, and basal cell carcinoma (BCC) accounts for approximately 80% of all skin cancers [1]
Langerhans cells are the dendritic cells of the epidermis that comprise 3%–5% of the total epidermal cell population [4] recognised by specific markers, such as CD207 [5] and CD1a [6]
The aim of the present study was to evaluate the percentage of Langerhans cells using CD1a in non-melanoma skin cancer, including BCC and squamous cell carcinoma (SCC) and to correlate this percentage with their clinicopathological features
Summary
Skin cancer is the most common cancer in Europe, the United States and Australia, and basal cell carcinoma (BCC) accounts for approximately 80% of all skin cancers [1]. According to the Egyptian National Cancer Institute, 78.5% of skin cancers are non melanocytic, including BCC (54.6%) and SCC (44.9%) [2]. Langerhans cells are the dendritic cells of the epidermis that comprise 3%–5% of the total epidermal cell population [4] recognised by specific markers, such as CD207 [5] and CD1a [6]. These molecular markers play functional roles in various aspects of Langerhans cells biology [7]
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