Abstract
BackgroundPatterns of recurrence help to inform surveillance of patients with resected gastroenteropancreatic neuroendocrine tumors (GEP-NETs). MethodsPatients with GEP-NETs in British Columbia, Canada (2004–2015) were reviewed. Associations between tumor characteristics, recurrence and survival were analyzed. ResultsAmong 759 patients, 41%, 25%, and 17% had grade 1, 2, and 3 disease, respectively. 387 patients had R0/R1 resections, of which 30% recurred (median 25 months). 5-year incidence of recurrence was 22% (grade 1), 46% (grade 2), and 59% (grade 3) (p < 0.001). Grade predicted distant recurrence (Grade 2 HR 1.89, 95% CI 1.16–3.07; p = 0.011; Grade 3 HR 3.29, 95% CI 1.81–5.99; p < 0.001). Compared to small bowel NETs, pancreas NETs had less peritoneal recurrence (OR 0.15, 95% CI 0.03–0.68, p = 0.014). No patients had isolated pulmonary recurrences. ConclusionHigher grade tumors and pancreatic NETs require more frequent surveillance. Evidence is limited for pulmonary surveillance.
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