Abstract
Recently it has been reported that naturally occurring inhibitors of tumor necrosis factor α (TNF-α) were demonstrated in urine of some acute febrile patients. We investigated whether TNF-α inhibitory activity in urine increases during acute Kawasaki disease (KD). TNF-α inhibitory activities in urine were measured by a cytotoxicity assay on the TNF-susceptible cell line L929. KD patients had increased TNF-α inhibitory activities in urine during the acute stage and returned to a normal range during the convalescent stage. Our results suggest that the TNF-α inhibitor in urine is part of the regulatory system of TNF-α, which might be responsible for vascular injury during acute KD.
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