Étudede la réponse immunitaire humorale au «vaccin rabique purifié pasteur après traitement post-exposition: Study of the humoral immune response 023 to the «pasteur purified rabies vaccine in post-exposure treatment

Abstract

Summary The purified inactivated Pasteur rabies vaccine was prepared on primary culture of foetal bovine kidney cells using the Pasteur fixed rabies virus (PV). A clinical trial in a post-exposure situation was carried out on a group of 130 volunteers. The vaccine was administered according to the WHO scheme for vaccines prepared on human diploid cells: 4 injections of 1.0 ml on days 0, 3, 7 and 14, followed by booster doses on days 30 and 90. This induced the production of neutralizing antibodies, detected from day 14. Neither local nor systemic adverse reactions of any importance were registered.