Abstract
The aim of the biochemical analysis of cerebrospinal fluid in support to clinical diagnosis of multiple sclerosis and inflammatory disorders of the central nervous system is the detection of intrathecal IgG synthesis. According to the European consensus report, we have developed a sensitive and specific iso-electric focusing method for detection of oligoclonal immunoglobulin banding in CSF and serum, and performed evaluation of blood-brain barrier and quantification of humoral immune response by albumin and immunoglobulin determination. We present a retrospective study of 537 patients having a CSF and serum pair analysed for intrathecal IgG synthesis study, 140 of them being suspected of multiple sclerosis according to Poser criteria. Quantitative and qualitative methods for IgG intrathecal detection are compared in the area of multiple sclerosis diagnosis contribution. This study confirms the interest to search IgG oligoclonal banding by the most sensible method (iso-electric focusing of oligoclonal IgG, according to the European consensus).
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