Abstract
Chronic kidney disease (CKD) is accompanied by tubulo-interstitial atrophy and fibrosis, regardless of the underlying cause. Disorders of the renal vasculature, the glomeruli or urinary drainage all culminate in chronic tubulo-interstitial damage, the severity of which is the histological feature that correlates best with progression to end-stage renal failure (ESRF). However, there are diverse conditions in which the tubulo-interstitium is the primary site of damage; these may be considered together without inferring a common aetiology or pathogenesis. The diseases classified as tubulo-interstitial nephritis are considered in this article.
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