Abstract
<h2>Abstract</h2> Chronic renal failure (CRF) is accompanied by tubulo-interstitial atrophy and fibrosis, regardless of the cause. Disorders of the renal vasculature, the glomeruli or urinary drainage all culminate in chronic tubulo-interstitial damage, the severity of which is the histological feature that correlates best with progression to end-stage renal failure (ESRF). However, there are diverse conditions in which the tubulo-interstitium is the primary site of damage, and these may be considered together without inferring a common aetiology or pathogenesis. The diseases classified as tubulo-interstitial nephritis are considered below. Inherited disorders of tubular function are discussed in <i>MEDICINE</i> <b>31:5</b>, 32, acute tubular necrosis (ATN) in <i>MEDICINE</i> <b>31:6</b>, 43, and the renal manifestations of myeloma on page 99.
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