Abstract
related conditions meeting MAG criteria and who underwent temporary GES. Methods: 12 patients (3 male, 9 female, mean age 51.2 years) were retrospectively reviewed for changes to symptom scores and physiologic measures after treatment. Patients had a variety of cancers including cervical, ovarian, uterine, breast, prostate and malignant melanoma. Symptoms scoring focused on three variables: nausea (N), vomiting (V), and GI total symptom score (TSS). Baseline physiologic profiles were measured by gastric emptying scans (1, 2 and 4 hr solid and liquid phases), cutaneous electrogastrogram (EGG) and proximal and distal mucosal electrogram (EG) frequencies. GI symptoms were measured over 5 days postplacement of temporary endoscopic GES. Gastric empyting scans were repeated after temporary GES placement. Patients were implanted under a Humanitarian Use Device (HUD) protocol. Temporary stimulation was performed as previously described (CTRN 00432835; GIE 2011;74:496-503). Results: Baseline gastric emptying studies in 7 of 12 patients displayed delayed gastric emptying (mean solid phase retention 19.2% at 4h, nl <10%; mean liquid phase retention 11.2% at 4h, nl <5% (Table 1). EGG (mean frequency 5.1 cpm) and EG (mean proximal freq. 5.5 cpm; mean distal freq. 4.9 cpm) showed evidence of neuromuscular dysfunction (normal 2.7-3.3 cpm) (Table 1). Symptom scores in N, V, and GI TSS showed significant reduction after gastric stimulator placement (Figures 1a, 1b, 1c). Gastric emptying improved at 4h in both solid and liquid phases after gastric stimulator placement (Table 1). Statistical significance was noted between baseline N, V, and TSS on days one (T1) through five (T5) after temporary stimulator placement (Figures 1a, 1b, 1c). Conclusion: A small sample of patients meeting criteria for MAG and undergoing temporary gastric stimulator placement experienced improvement in their symptoms and gastric emptying time when compared to baseline. This retrospective study suggests that GES may provide a potential therapeutic option for patients with MAG. Data evaluating these patients after permanent GES placement is currently being gathered. Further prospective studies of MAG using temporary and permanent GES may be warranted. Physiologic Measures of MAG Patients
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
