Abstract
(N = 4 or 5). 5) Administration of COX-2 inhibitor NS-398 at 10 mg/kg partially but significantly reduced sensory neuron hyperexcitability and improved visceromotor response induced by lumen distention (N = 5 or 6).Conclusions:Our study reveals a novel mechanism of peripheral sensitization in the gut that tonic lumen distention induces mechano-transcription of the pain mediator COX-2 in colonic SMC, which contributes to persistent VHS.
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