Abstract
G A A b st ra ct s despite higher levels of apoptosis (p=0.02). Levels of sCD14 and IL-6 were elevated during HIV infection. Soluble CD14 was elevated in both viremic (p=0.05) and ART-suppressed subjects (p=0.0006), and was positively correlated with levels of epithelial apoptosis (rho: 0.55, p=0.04) in suppressed subjects. Conclusions: HIV increases the levels of CEC apoptosis, which fail to normalize during suppressive ART in immunologic non-responders. The level of intestinal apoptosis was associated with innate immune activation. While the causal pathways remain unclear, strategies to improve persistently elevated levels of apoptosis and mucosal injury may ameliorate systemic inflammation during chronic HIV infection.
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