Abstract
The inhibitory effect of iodide on thyroid release of 125I-iodine was examined using McKenzie's bioassay method. Iodide did not inhibit the action of TSH or LATS when injected simultaneously with or just before injection of TSH or LATS. A significant inhibitory effect on hormone release was observed if the animals were treated with KI for 24 hr before TSH or LATS was administered. The ratio of 127I-PBI to 127I-TI (total iodine) was decreased in the groups receiving KI. The ratio of 125I-PBI to 125I-TI was not changed. From calculations of the specific activity of thyroid PBI (ratio of 125I-PBI/127I-PBI), any dilution effect of newly bound 127I in the thyroid was found to be negligible. Excess iodide directly blocks the release of thyroid hormone caused by TSH or LATS. (Endocrinology 84: 1305, 1969)
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