Abstract
Summary In rabbits pretreated with the nonselective monoamine oxidase (MAO) inhibitors pheniprazine or tranylcypromine, administration of tryptamine evoked a marked elevation in colonic temperature. On the other hand, pretreatment with clorgyline or pargyline, which preferentially inhibit MAO-A and MAO-B respectively, were generally unable to promote tryptamine-induced hyperthermia. However, higher doses of clorgyline or pargyline which inhibit MAO nonselectively did result in significant hyperthermic responses. These data demonstrate the need to inhibit both MAO-A and MAO-B for manifestation of the hyperthermic effect of tryptamine in rabbits.
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