Abstract
Studies on biochemical changes in sera from Trypanosoma lewisi infected rats were initiated to determine whether any correlation exists with metabolic changes reported to occur in the parasite. The levels of inorganic phosphate and ATP hydrolyzing enzymes in rat sera paralleled the parasitemia of T. lewisi throughout the infection. Creatine phosphokinase and ornithine carbamyl transferase activity were altered as a result of the infection. A hypoglycemic condition was observed during the time when the parasitemia was greatest in T. lewisi infected rats. The data indicate that metabolic changes in the rat occur concurrent with physiological and biochemical alterations in the parasites during infection. The interrelationships between the host and the parasite are discussed.
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