Türk Çocuklarında Anjiyotensin Konverting Enzim Gen Polimorfizmi (İnsersiyon/Delesyon) ve Sepsis Klinik Durumları Arasındaki İlişki

Abstract

ABS TRACT Objective: It has be en pos tu la ted that ge ne tic pre dis po si ti on may inf lu en ce the sus cep ti bi lity to in fec ti on and the di se a se out co me. The D al le le of the an gi o ten sin-con ver ting enz yme (ACE) ge ne is as so ci a ted with many di se a ses. Ho we ver, the re are only few re ports ava i lab le abo ut in fec ti on. We ha ve in ves ti ga ted the as so ci a ti on bet we en ACE I/D poly morp hism and sep sis, its cli ni cal fe a tu res such as acu te res pi ra tory dis tress syndro me (ARDS), mul ti or gan dysfunc ti on syndro me (MODS) and mor ta lity. Material and Met hods: Ni nety-eight chil dren who had be en di ag no sed with sep sis and 100 he althy in di vi di u als we re inc lu ded. The pa ti ents we re di vi ded in to gro ups ba sed on the pre sen ce of ARDS, MODS and sur vi vor or non sur vi vor. The ACE ge ne poly morp hism was analy zed by the poly me ra se cha in re ac ti on. Re sults: The re was no sta tis ti cal dif fe ren ce bet we en the con trol and pa ti ent’s ge noty pe (p= 0.29). No evi den ce emer ged re gar ding the as so ci a ti on of ACE I/D poly morp hism with MODS, but the re was evi den ce of as so ci a ti on with sep sis-re la ted ARDS. It was fo und that carr ying D/D ge noty pes in cre a sed the risk of the ha ving ARDS 4.5 fold (95%CI 1.15-19.6, p= 0.028). On the ot her hand, the re was not sta tis ti cally sig ni fi cant dif fe ren ce be t we en ACE ge ne poly morp hism and mor ta lity. Conc lu si on: In our study, the de le ti on poly morp hism in an gi o ten sin-con ver ting enz yme ge ne is as so ci a ted with in cre a se in the risk of sep sis-re la ted ARDS but not MODS and mor ta lity in Tur kish chil dren.