Tris[(2‐ oder 4‐)C9–10‐isoalkylphenyl]phosphorthioat [MAK Value Documentation in German language, 2016

Abstract

Tris[(2‐ or 4‐)C9–C10‐isoalkylphenyl]phosphorothioate The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the maximum concentration of tris[(2‐ or 4‐)C9–C10‐isoalkylphenyl]phosphorothioate at the work place (MAK value), considering all endpoints. Tris[(2‐ or 4‐)C9–C10‐isoalkylphenyl]phosphorothioate is a UVCB substance (substances of unknown or variable composition, complex reaction products or biological materials). It is a mixture of triphenylthiophosphates substituted with a C9‐C10 branched alkyl chain per phenyl moiety in ortho or para position. Toxicokinetic or metabolism data as well as inhalation studies with repeated exposure are lacking. Target organs could not be determined after oral application of up to 1000 mg/kg body weight and day in a 28‐day study in rats. Because of the high molecular mass of the substance, its oral absorption is assumed to be much less than 100%. Therefore, no MAK value can be calculated from the oral NOAEL of 1000 mg/kg body weight per day and the substance is listed in Section II b of the List of MAK and BAT Values. The substance is slightly irritating to skin and eyes of rabbits. Contact sensitization was not observed in guinea pigs. Data on reproductive toxicity are only available from a read‐across substance yielding a NOAEL of 250 mg/kg body weight and day for toxicity to fertility and postnatal development in a test in rats according to OECD Test Guideline 421. The clastogenicity seen in an in vitro test could not be confirmed in vivo. There are no carcinogenicity studies. Due to the high molecular mass, skin absorption is expected not to contribute significantly to the systemic toxicity.