Abstract
Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Methods: Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated. Results: The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF. Conclusion: The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.
Highlights
Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems
The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern
SBA-15 pattern showed the (100), (110), and (200) reflection peaks which are characteristic of an ordered mesoporous silica structure with two dimensional hexagonal nanochannels
Summary
Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 μg h-1 in the SBF. Tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy. Citalopram is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. This drug acts by restoring the balance of serotonin in the brain. Citalopram exists in plasma or blood in the concentrations within the range of 50-400 μg/L in patients receiving the drug therapeutically, 1000-3000 μg/L in people surviving the acute overdose and 3-30 mg/L in not-survived patients.[8,9,10] it was reported to be the most dangerous SSRI in overdose.[11]
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