Abstract
Triple-negative breast carcinomas constitute a wide spectrum of lesions, mostly being highly aggressive. Nevertheless, some special histologic subtypes can have low malignant potential. The purpose of the present paper is to review diagnostic criteria and prognostic parameters of breast neoplasms of special histotypes. Specifically, adenoid cystic carcinoma, adenomyoepithelioma, acinic cell carcinoma, mucoepidermoid carcinoma, tall cell carcinoma with reverse polarity, and secretory carcinoma will be discussed. For each tumour, definition and morphological and molecular features, together with prognostic parameters, will be presented. Paradigmatic cases will be illustrated.
Highlights
Triple-negative breast carcinomas (TNBCs) are invasive breast carcinomas lacking oestrogen receptor (ER) or progesterone receptor (PR) expression and HER2 amplification
Normal breast glands are composed of different cells, not all expressing hormone receptors but all of them having the ability to transform into malignant tumours of varying clinical behaviour
Despite the attention toward these histologic subtypes has grown in the last decade, knowledge on TNBC of low malignant potential is still limited due to their rarity
Summary
Triple-negative breast carcinomas (TNBCs) are invasive breast carcinomas lacking oestrogen receptor (ER) or progesterone receptor (PR) expression and HER2 amplification. AdCC is an invasive carcinoma composed of epithelial and myoepithelial cells, arranged in tubular, cribriform and solid structures [2]. Strong and diffuse MYB expression by immunohistochemistry can be used to support a diagnosis of AdCC, reported in 65–100% of the cases [8–10]. Rare cases of AdCC associated with adenomyoepithelioma (AME) have been reported [16].
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