Abstract
Pulmonary artery hypertension is a refractory disease that severely affects cardiopulmonary function, mainly resulting in irreversible pulmonary vascular remodeling. Current surgical treatment of this disease is not very effective and drug treatment is targeted at relieving symptoms, improving the quality of life of patients, and preventing disease progression. The purpose of this present study was to reveal the regulatory effects of trimethoxystilbene on the serum levels of nuclear factor kappa B, interleukin-6, and tumor necrosis factor-α in a rat model of pulmonary artery hypertension and to explore the possible underlying mechanisms. Healthy Sprague Dawley rats were randomly assigned to experimental groups and treated with monocrotaline to establish the model, and we found a significant difference in the expression levels of nuclear factor kappa B, interleukin-6, and tumor necrosis factor-α between the experimental and control groups. These results suggest that trimethoxystilbene significantly reduced the inflammatory factor levels in pulmonary hypertensive rats, providing us with new potential strategies for elucidating the mechanisms of action of trimethoxystilbene in the treatment of pulmonary artery hypertension.
Highlights
BioMed Research International revealed “the French Paradox.” e French Paradox is a phenomenon in which a high-fat diet is negatively correlated with the incidence of coronary heart disease, and additional studies have shown that the Res in red wine has a protective effect on the heart [7]
There was an increase in the right heart cavity diameter, abnormalities in the shape and motion of the interventricular septum, an increase in right ventricular wall thickness, and expansion of the main pulmonary artery. e hematoxylin and eosin (H&E) staining and triphosphate (dUTP) nick-end labeling (TUNEL) assay of the myocardial cells showed hypertrophy of myocardial cells with a disordered arrangement. e TUNEL assay showed an increase in the apoptosis of myocardial cells, which indicated the successful establishment of the Sprague Dawley (SD) rat model of PAH using monocrotaline. e results are shown in Table 1 and Figure 1
Movement with a corresponding pulmonary capillary wedge pressure (PCWP) < 15 mmHg constitutes a diagnosis of PAH. e main characteristic of PAH is a progressive increase in pulmonary artery resistance, which eventually leads to right-sided heart failure [12]. e premise for performing this speci c research on PAH was to successfully establish an experimental model of pulmonary hypertension
Summary
BioMed Research International revealed “the French Paradox.” e French Paradox is a phenomenon in which a high-fat diet is negatively correlated with the incidence of coronary heart disease, and additional studies have shown that the Res in red wine has a protective effect on the heart [7]. Trimethoxystilbene (TMS) is a derivative of 3,5,4-trihydroxytrans-stilbene, known as Res. We investigated TMS as a raw material in experimental research studies and were able to increase its lipid solubility using a methylation reactionbased synthesis process that introduced three methyl groups, which enhanced the ability of TMS to penetrate the cell membrane. E present study aimed to explore the effects of TMS on PAH pathogenesis by determining differences in the relative transcription factor and cytokine expression levels in the lung tissue of a Sprague Dawley (SD) rat model of PAH after intervention with TMS treatment
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