Abstract
Two new sesquiterpene phenol trimers, tridysoxyphenols A ( 2 ) and B ( 3 ), along with two known compounds, namely a sesquiterpene phenol, (+)-7-hydroxycalamenene ( 1 ), and a tetralone derivative, 4-hydroxy-4,7-dimethyl- α -tetralone ( 4 ), were isolated from the leaves of Dysoxylum parasiticum (Osbeck) Kosterm. The structures of 2 and 3 were elucidated using nuclear magnetic resonance (NMR) spectroscopy, ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy, high-resolution electrospray ionization time-of-flight mass spectrometry (HR-ESI/TOF-MS), and time-dependent density functional theory (TDDFT) calculations of the electronic circular dichroism (ECD) spectroscopic data. No cytotoxic activity was observed for any of the isolated compounds at low concentrations, although compound 1 suppressed the viability of HL60 cells at 119.85 ± 10.03 μM. • The metabolites isolated from the leaves of Dysoxylum parasiticum were studied. • Tridysoxyphenols A and B represent the trimeric sesquiterpene phenols. • Their structures were elucidated on the basis of spectroscopic analyses.
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