Abstract
PurposeThe performance of carrier-based dry powder inhaler (DPI) formulations can be critically impacted by interfacial interactions driven by tribo-electrification. Therefore, the aim of the present work was to understand how distinct API particle characteristics affect the charging behaviour of blends intended for DPI delivery.MethodsSalbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs. D-mannitol was selected as a model carrier. The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe.ResultsThe spray-dried SBS (amorphous and spherical) charged positively and to a higher extent than jet milled SBS (crystalline and acicular) that charged negatively and to a lower extent. D-mannitol charged positively and to a higher extent than the APIs. All drug-excipient blends charged negatively and differences were found between the spray-dried and jet milled SBS blends at 2% and 5% drug loads.ConclusionsIt was demonstrated how distinct solid-states, particle shape, size and morphology as well as different water contents of the different materials can affect tribo-charging. For their binary blends, the amount and nature of fines seem to govern inter-particle contacts critically impacting charge evolution.
Highlights
Powder tribo-charging is known to greatly affect the industrial processing and performance of particulate and granularS
Scanning Electron Microscopy (SEM) images in Fig. 2a and b show distinctive morphologies for the Salbutamol sulphate (SBS) prepared by spray-drying (SBS SD) and jet milling (SBS JM)
The particle size of both SBS SD and SBS JM samples were in the inhalable size range (< 5 μm)
Summary
Powder tribo-charging is known to greatly affect the industrial processing and performance of particulate and granularS. Powder tribo-charging is known to greatly affect the industrial processing and performance of particulate and granular. Part of this work was presented at the Drug Delivery to the Lung (DDL) Conference 28, 2017, Edinburgh, Scotland. Pharm Res (2019) 36: 80 materials, including pharmaceutical solids. Issues such as unintended particle agglomeration and adherence to container surfaces, can arise due to tribo-charging, potentially leading to feeding/dosing inaccuracy and mixing inhomogeneity [1]. Powder tribo-charging can directly impact the performance of dry powder inhalers (DPIs) [2]. DPIs usually contain inhalable-size active pharmaceutical ingredient (API) particles (1 – 5 μm) adhered to the surface of a larger carrier material (usually 50 – 200 μm) [3]
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