Abstract
Isotonic solution of MH was ingested by normal volunteers in 18 studies. MH caused significant though minor elevations in blood glucose between one and one-half and four hours after ingestion, without significant change in plasma insulin levels. Reduction of K values was noted when intravenous glucose was injected two hours after MH ingestion. Compared with control studies, there was also a reduction in the mean initial plasma insulin levels following glucose injection. No evidence of toxicity or unpleasant symptoms were noted at lower doses, but nausea and diarrhea were produced at a dose level of 20 gms. The quantity of MH excreted in the urine was not related to ingested dose. In a patient with islet cell carcinoma, the ingestion of 15 gms produced no clinically significant change, hypoglycemia developing at the time of peak blood MH concentration. Although orally administered MH is unlikely to have any clinical value, it has been demonstrated to exert effects in man similar to those noted in animal preparations.
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