Abstract
BackgroundTo examine trends in serum lipids in population in Northwestern Xinjiang between 1998 and 2015 and to provide clues for future prevention.MethodsWe enrolled 5,142 adults aged ≥30 years from seven independent cross-sectional studies conducted in 1998–2000, 2007–2008, and 2015. Blood lipid profiles, such as total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured.ResultsThe mean age was 48.5 years in 1998–2000, 47.9 years in 2007–2008, and 53.7 years in 2015. There was a declining trend in the prevalence of dyslipidemia among adults in northwestern Xinjiang. Mean LDL-C decreased during the same period, while mean HDL-C showed the opposite trend. Mean TC was 4.79 mmol/L in 1998–2000, 5.17 mmol/L in 2007–2008, and 4.59 mmol/L in 2015. The trend of mean TG was similar to that of TC. The prevalence of dyslipidemia was closely related with male gender, Mongolian ethnicity, hypertension, obesity, elevated fasting blood glucose, smoking, and drinking.ConclusionBetween 1998 and 2015, favorable trends in lipid levels have occurred among adults of Northwestern Xinjiang. However, further efforts are needed.
Highlights
Cardiovascular disease (CVD) is the leading cause of death worldwide and accounts for 31% of all global deaths.[1]
The World Health Organization (WHO) reported that, about 17.7 million people died from CVD worldwide in 2015.1 Epidemiologic surveys have demonstrated that high concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and low levels of high-density lipoprotein cholesterol (HDL-C) are major risk factors for CVD.[2,3,4,5,6,7,8]
In China, the prevalence of dyslipidemia in adults has increased from 18.6% in 2002 to 40.1% in 2012.14,15 Elevated serum cholesterol levels are expected to result in 9.2 million extra CVD events in China during the 20 years.[16]
Summary
Cardiovascular disease (CVD) is the leading cause of death worldwide and accounts for 31% of all global deaths.[1] The World Health Organization (WHO) reported that, about 17.7 million people died from CVD worldwide in 2015.1 Epidemiologic surveys have demonstrated that high concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and low levels of high-density lipoprotein cholesterol (HDL-C) are major risk factors for CVD.[2,3,4,5,6,7,8] Many previous studies have proved that mortality and morbidity from CVD can be reduced by lowering the serum lipids levels.[3,4,9,10,11,12]. A vast and multi-ethnic province, is located in the northwest edge of China It is the largest Chinese administrative region and takes up about one-sixth of the country’s territory. To examine trends in serum lipids in population in Northwestern Xinjiang between 1998 and 2015 and to provide clues for future prevention
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