Abstract
Traumatic neuropathic pain caused by traumatic neuroma has long been bothering both doctors and patients, the mechanisms of traumatic neuropathic pain are widely discussed by researchers and the treatment is challenging. Clinical treatment of painful neuroma is unclear. Numerous treatment modalities have been introduced by experts in this field. However, there is still no single standard recognized treatment.Different forms of treatments have been tested in animals and humans, but pharmacotherapies (antidepressants, antiepileptics) remain the basis of traumatic neuropathic pain management. For intractable cases, nerve stump transpositions into a muscle, vein or bone are seen as traditional surgical procedures which provide a certain degree of efficacy. Novel surgical techniques have emerged in recent years, such as tube guided nerve capping, electrical stimulation and adipose autograft have substantially enriched the abundance of the treatment for traumatic neuropathic pain.Several treatments show advantages over the others in terms of pain relief and prevention of neuroma formation, making it difficult to pick out a single modality as the reference. An effective and standardized treatment for traumatic neuropathic pain would provide better choice for researchers and clinical workers.In this review, we summarized current knowledge on the treatment of traumatic neuropathic pain, and found a therapeutic strategy for this intractable pain. We tried to provide a useful guideline for choosing the right modality in management of traumatic neuropathic pain.
Highlights
IntroductionPeripheral neuroma caused by injuries and surgical procedures can result in traumatic neuropathic pain, functional impairment and psychological distress, severely decreasing the quality of life [1]
Traumatic neuropathic pain caused by traumatic neuroma has long been bothering both doctors and patients, the mechanisms of traumatic neuropathic pain are widely discussed by researchers and the treatment is challenging
Peripheral neuroma caused by injuries and surgical procedures can result in traumatic neuropathic pain, functional impairment and psychological distress, severely decreasing the quality of life [1]
Summary
Peripheral neuroma caused by injuries and surgical procedures can result in traumatic neuropathic pain, functional impairment and psychological distress, severely decreasing the quality of life [1]. A traumatic neuroma is a tangle of neural fibers and connective tissue that develops following nerve injury. It usually presents as a firm, oval, whitish, slowly growing, palpable and painful nodule, not larger than 2 cm. It may be associated with paresthesia over the injured area [2]. Traumatic neuropathic pain can cause the patient to feel burning, stabbing, raw, gnawing or sickening sensations. Traumatic neuropathic pain can cause the patient to feel burning, stabbing, raw, gnawing or sickening sensations. [2]
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