Abstract
Objective To investigate the role of neurosurgical decompression in the treatment of neuroblastoma with intraspinal extensions.Methods Between February 2000 and May 2007,10 patients (7 male and 3 female,5 age less than 6 months old,3 between 6 months and 12 months old,2 between 1 and 2 years old) were diagnosed as intraspinal neuroblastoma and underwent surgical resection at Xin-Hua hospital in Shanghai.Results Surgical decompression with laminectomy and removal of tumor were performed in 9 patients.One case was diagnosed in other hospital by biopsy,had treated with two courses of chemotherapy,and then ccme to our hospital for neurosurgical decompression.Nine cases were abandoned treatment after surgery,only one followed the chemotherapy.Seven cases were alive in eight followed-up cases.Among them,tumor regression happened in 5 cases,spontaneous maturation in 1 case,and total disappearance after chemotherapy in 1 case.Conclusions The prognosis of patients with intraspinal neuroblastoma is excellent even without radical operation.These findings suggest the possibility that neurosurgical decompression is associated with favorable prognosis.Based on present knowledge,surgical decompression combined with chemotherapy maybe adequate for patients less than 6 months old with intraspinal neuroblastoma. Key words: Neuroblastoma; Spinal cord compression; Tumor regression, Spontaneous
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