Treatment of multi-position condyloma acuminatum using topical CO2 laser combined with photodynamic therapy - Report of 6 cases.

Abstract

Condyloma acuminatum(CA) is a venereal disease associated with a high rate of recurrence due to the rapid replication and subtle immune escape mechanism of Human Papillomavirus(HPV). Topical CO2 laser can remove verruca accurately. Photodynamic therapy with 5-aminolevulinic acid(PDT-ALA) is also an effective therapy which targets on HPV infected sites. Some studies demonstrate that when combined with use of CO2 lasers, photodynamic therapy can become more effective. We attempted to clinically cure a series of CA grown on cervix, urethra, urinary meatus, vulva, crissum and anal canal with treatment of topical CO2 laser combined with ALA photodynamic therapy and report herein 6 cases. Topical CO2 laser combined photodynamic therapy for CA achieved a complete response after 3 courses of treatment. No recurrence was found after 6-month follow-up in 6 cases, and the HPV PCR detection for all was changed from positive to negative. When it comes to CA treatment, the combination of photodynamic therapy and CO2 laser usage can give full play to their own respective superiority, and the curative effect is more significant.