Abstract
To examine the safety and efficacy of fluconazole in patients with a permanent nephrostomy or suprapubic catheter in the prevention of candiduria. Twenty patients with a nephrostomy or suprapubic catheter who had at least two positive urine cultures with a minimum of 15,000 col/mL Candida counts were studied. The catheters were irrigated with fluconazole solution prepared as 1 mg/mL with normal saline. Repeated urine cultures were obtained. In 17 patients Candida was eradicated from the urine by the third to sixth day of irrigation. No side-effects were noted. Fluconazole as an irrigant is effective and safe in the treatment of catheter-associated candiduria, which can be eliminated without changing the catheter.
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