Abstract
BackgroundThe purpose of this study is to investigate the clinical effectiveness of staging radioactive particle implantation guided by computed tomography (CT) and fiber–optic bronchoscopy in treating cancerous large airway stenosis.MethodsA total of 102 patients were included; 57 had undergone staging radioactive particle implantation guided by CT and fiber bronchoscopy and 45 did not. Patients were evaluated by CT and fiber–optic bronchoscopy to determine the feasibility of the implantation of radioactive seeds for the treatment of cancerous large airway stenosis. The treatment planning system (TPS) was used to plan the doses. Radioactive seeds were implanted using fiber–optic bronchoscopy. One week later, CT-guided implantation of radioactive seeds was performed.ResultsThe clinical evaluation showed complete, partial, slight, and non-response in 38, 14, 5, and 0 patients, respectively. None of the patients were found with serious complications. The diameter of the affected airway, Karnofsky score, dyspnea index, survival, and quality of life of the patients in both groups was significantly higher and significantly different after the treatment (P < 0.05). The dyspnea index was significantly lower in the treatment group as compared with the control group (P < 0.001).ConclusionCT- and fiber bronchoscopy-guided staging radioactive particle implantation has definite treatment effectiveness in treating cancerous large airway stenosis. It should be widely used in clinical practices.
Highlights
The purpose of this study is to investigate the clinical effectiveness of staging radioactive particle implantation guided by computed tomography (CT) and fiber–optic bronchoscopy in treating cancerous large airway stenosis
From March 2011 to December 2015, 57 patients with cancerous large airway stenosis were successfully treated at our department using computed tomography (CT) and fiber bronchoscopy-guided staging radioactive particle implantation
CT- and fiber bronchoscopy-guided staging radioactive particle implantation were performed to treat the cancerous large airway stenosis. The patients in both groups met the following criteria: (1) with cancerous large airway stenosis; (2) the lung cancer was confirmed by pathological or histological examinations; (3) could not receive radical operation due to various reasons; and (4) without absolute contraindication to fiber bronchoscopy treatments
Summary
The purpose of this study is to investigate the clinical effectiveness of staging radioactive particle implantation guided by computed tomography (CT) and fiber–optic bronchoscopy in treating cancerous large airway stenosis. Radioactive particles are being more and more commonly used to treat lung cancer in China These particles are generally implanted percutaneously or by surgery [1, 2], but the implantation can be very difficult in some patients due to the location of the tumor, especially for cancerous large airway stenosis. In such patients, the radioactive particles could be implanted permanently under the guidance of fiber bronchoscopy. From March 2011 to December 2015, 57 patients with cancerous large airway stenosis were successfully treated at our department using computed tomography (CT) and fiber bronchoscopy-guided staging radioactive particle implantation. The treatments and outcomes were reported in this retrospective study
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