Travmatik Beyin Hasarı Sıçan Modelinde Sesamol’ün İkincil Yaralanmaya Karşı Koruyucu Etkileri

Abstract

Objective: Sesamol is a powerful antioxidant, anti-inflammatory, antiapoptotic, and neuroprotective chemical. This study aimed to investigate the histopathological effects of sesamol in a rat traumatic brain injury (TBI) model. Material and Methods: Thirty-two male rats were divided into the following four groups: control, trauma, vehicle, and sesamol. All groups were subjected to TBI, and immediately after trauma saline and sesamol (100 mg/kg) were administered intraperitoneally to the vehicle and sesamol groups, respectively. At 24th hour of TBI, brain samples were collected, and histomorphological investigation of brain parenchyma was performed using electron and light microscopy. Results:On histopathological investigation, TBI induced brain injury was lesser than trauma and vehicle groups in the sesamol group. Compared to the trauma group, in the sesamol group there was less perivascular region edema. The neuronal processes of the sesamol group also displayed less intracellular edema and vacuoles. Conclusion:The results of the current study revealed for the first time that sesamol exhibits neuroprotective effects against TBI.